The Pick 6 can be the most lucrative wager in horse racing.
It can also be the most expensive.
That paradox succinctly explains why the wager can be tilted in favor of handicappers with larger bankrolls. Given how quickly combinations can add up, the $2 bettor cannot keep pace with players who can wager $300 or $500 without blinking an eye.
Syndicates can help small players compete, but there are times when even the $2 player can take a stab at a Pick 6.
What matters here is finding the right spot.